Is expensive Nurofen better than cheap Ibuprofen?

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Now, not being a marketing person I’m really not in favour of creating different versions of the same thing and charging more for them. But given the recent news headlines, the question many people have is, ‘Is Nurofen better than Ibuprofen?’… even though they are the same thing.

I know people who swear that Ibuprofen simply isn’t strong enough for them and that they find that only Nurofen works for them. They use a similar argument for Panadol vs Paracetomol, preferring to pay several times more for the branded Paracetamol.

However, an interesting thing happens when you do pay more for the same thing. In the 1980s, a study was performed where over 800 women were given one of two versions of the same aspirin for headache pain.

One group of women received an expensive looking version in quality packaging labelled as ‘Aspirin’, and another group received a cheap looking version in plain packaging labelled as ‘Analgesic’. However they were both the exact same aspirin, merely in different packaging and with a different name.

The other two groups of women received placebos but one groups’ placebos were expensively packaged and labelled ‘Aspirin’ and the other groups’ were in plain aspirin packaging and labelled ‘Analgesic’.

Now, you’d expect both versions of aspirin to work the same, given that they are both aspirin, and both placebos to work the same, given that they are, well, sugar. But that’s not what the study found.

The expensively packaged aspirin worked better than the cheaper looking version, even though they were the exact same drug. And interestingly, the expensive looking placebo also worked better than the cheap looking placebo. And funnily enough, the expensive looking placebo was nearly as good as the cheap looking aspirin. So what’s going on?

Basically, we associate price with quality so when we pay more for something, we expect it to work better. And it turns out that what we expect or believe actually changes what happens in the brain.

It’s not psychosomatic! It’s not ‘all in the mind’! Research into the placebo effect shows us that belief changes brain chemistry. Believing that something is going to relieve pain actually causes your brain to make it’s own versions of morphine (known as endogenous opiates).

And our beliefs about how the medicine is administered matter too. In the US, an injection of a placebo for pain works about 50% better than a placebo tablet even though they are both placebos. In the UK, it’s reversed. A placebo tablet for pain works a little better (about 10%) than a placebo injection. Why the difference? Surely if they are all placebos they should work exactly the same. Again, the difference is down to what we believe.

In the US, people talk about ‘getting a shot’ and so people in the US generally believe that injections are better for pain than tablets are. On the other hand, people in the UK talk about ‘popping pills’ and so UK people tend to believe in tablets for pain. It comes down to cultural language and that language reflects what we believe.

The bottom line is that things are never ‘all in the mind’. Our beliefs change our brain chemistry (and also what’s going on all throughout the body) and that change can often produce healing effects.

Interesting though this is, and also an untapped resource in terms of our capacity to affect our own health if we learn some mental techniques, the issue that bothers people is that the relatively high pricing of branded medicine seems to be all about profit.

I can’t say for sure that pharmaceutical companies aren’t aware of how to boost the placebo effect and that they price things higher to tap into it. I left the industry in 1999 so I’m not on the ball with their knowledge base. I spent four years in drug development after my PhD in organic chemistry. Given the time since I left I really can’t comment on their motivations.

Certainly, my colleagues back then were definitely not knowledgeable about how the placebo effect works and the general opinion was that it was simply a nuisance that got in the way of achieving a true measure of how well a new drug was working in a clinical trial.

But in the words of Fabrizio Benedetti, professor of physiology and neuroscience at the University of Turin School of Medicine and world authority on the placebo effect, in a paper published in the journal Annual Review of Pharmacology and Toxicology, he wrote:

The placebo effect has evolved from being thought of as a nuisance in clinical pharmacological research to a biological phenomenon worthy of scientific investigation in its own right.”

I would say that there is definitely more to the mind than most people think. The human mind really is a relatively untapped resource in its ability to bring about changes in the brain and body. The challenge for us, really, is learning how to tap into this phenomenon and learning how to direct and control it.

That’s my motivation for studying and writing about the mind-body connection.

Further reading: For many studies on the mind-body connection and other mind-body phenomena, including meditation, neuroplasticity, and visualisation strategies for harnessing the mind-body connection, see my book: ‘How Your Mind Can Heal Your Body’.

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  1. Robert Sutherland on December 17, 2015 at 7:19 pm

    Empowering blog David, thanks for sharing!

    • David R. Hamilton PhD on December 18, 2015 at 8:24 am

      Thanks Robert. 🙂

  2. Joe Hayes on December 21, 2015 at 6:13 pm

    Hi David,
    Because I’ve been having such amazing results with many of your visualisation techniques I had to share some extraordinary experiences centred around your article and the mind body connection. On more than several occasions I went to buy Nurofen for various pains, but never actually used it when I got home because the pain had gone and I forgot all about it. I think the fact that I made a conscious effort to go out and buy Nurofen, plus my strong belief system, the brain chemistry already started to work to produce the result I was expecting to happen. I never realised this until I discovered 3 unopened boxes of Nurofen recently.
    Joe Hayes

    • David R. Hamilton PhD on December 22, 2015 at 8:43 am

      Excellent, Joe. Thanks for this. So true… often just the conscious effort and the little bit of unconscious relief, knowing that the pain will be dealt with soon, actually kicks in the brain chemistry changes required to reduce pain. 🙂

  3. ОООВалок_Филат on February 10, 2017 at 1:31 pm

    RE:Is expensive Nurofen better than cheap Ibuprofen? | David R Hamilton PhD НПП Валок Производство роликов МНЛЗ

  4. Mrs Sylvia Barwick on November 26, 2023 at 11:22 pm

    Just had hand surgery and bought the good ole expensive double strength Nurofen which states the ingredient is 400mg Ibuprofen. I thought why didn’t I just get normal Ibuprofen. It’s the same damn thing LOL. I find it almost sad that we get tricked into spending more money on brands because of our crazy minds. I guess since day one we are programmed into believing expensive is the best and we should strive for it.

  5. Telkom University on December 24, 2023 at 7:52 am

    Is Nurofen, despite its higher cost, more effective than the less expensive Ibuprofen?

  6. Telkom University on January 16, 2024 at 11:55 am

    Does the higher cost of Nurofen indicate a greater efficacy compared to the affordability of Ibuprofen?

  7. Swasta Terbaik Jawa Timur on June 3, 2024 at 7:42 am

    thanks for your information

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