Can your brain learn to respond to a placebo?

DNA with light shining behind it

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Imagine how much money the NHS or medical insurance companies would save if we could swap some of our drugs for placebos after a few days of taking them?

As far as some exciting new research is concerned, it certainly seems to be a possibility.

A placebo is an empty pill; that much most people know. But just like someone can learn to play tennis or hit a golf ball and get better over time, a new study has found that the brain can learn to respond to a placebo and can get better at it over time too.

The research involved 42 patients with Parkinson’s disease, who had had the disease for between 11 and 24 years. It was led by Fabrizio Benedetti, professor of physiology and neuroscience at the University of Turin Medical School. It was published in the Journal of Neurophysiology.

Any improvements in the patients were assessed by a) measuring muscle rigidity at the wrist and b) measuring the activity of individual neurons in the thalamus of the brain.

The patients were initially given a placebo and the scientists measured their responses. After one placebo, there was no clinical improvement and no changes in individual neurons.

Next, a patient was given an injection of the anti-Parkinson’s drug, apomorphine. The following day they were due to receive their second injection of apomorphine but it was secretly swapped for a placebo injection. Even though they received a placebo, there was a measureable clinical improvement and an increase in activity of neurons on receiving the placebo.

That wasn’t the half of it though. If they received two doses of apomorphine before the placebo, the clinical improvement and neuronal activation was ever greater, and greater still after receiving three prior doses of apomorphine, and even greater yet if they received four doses before their placebo.

The rule they found was this: “The greater the number of previous apomorphine administrations, the larger the magnitude and the longer the duration of the clinical and neuronal placebo responses.”

Amazingly, in patients who received a placebo after four previous administrations of apomorphine, the placebo gave them the exact same physical improvement as the drug did.

In other words, once the person (and their brain) learns what to expect from a drug, the drug can be swapped for a placebo – at least in the case of apomorphine and Parkinson’s disease.

It’s important to point out here that this is not just ‘all in the mind’ or that only ‘weak minded, or gullible, people’ respond to placebos, which is a common sceptical response.

Let’s think about it for a second: The study showed actual physical changes in the brain when a person received a placebo. It is certainly not ‘all in the mind’. And I would argue, in fact, that it takes a strong mind to cause these physical and neurological changes!

It is these brain changes that lead to physical improvement. So rather than it being ‘all in the mind’, the mind, in fact, causes neurological changes in the brain.

Indeed, many previous studies have shown that expectation drives the placebo effect. Benedetti defines a placebo as: “The administration of an inert treatment along with a positive psychosocial context inducing positive expectations of clinical improvement.”

That is: a patient expects a result and this expectation alters their biochemistry to bring them the result that they are expecting.

Think of what this means. A placebo is an empty pill. Typically made of sugar or chalk, it has no pharmacologically active ingredients. But in the mind of the person receiving it, she or he imagines it to be a medicine that will bring them relief or improvement.

It is this imagined, expectation of improvement that activates the placebo response, altering activity in the brain and delivering the person the very result that they are expecting.

So, given that healthcare seems to be all about money these days – of course, it’s about health, really, but everything seems to have a price tag! – I wonder how much scope there is, given further research, to swap some drugs for placebos after a person’s brain has learned what the drug does.

Now we’re really entering the days of taking seriously that the mind impacts the body quite significantly.

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  1. Angela Walker on May 31, 2017 at 10:45 am

    Could you do a study on this? I mean, really, take a NHS clinical practice and take over!! Actually, please come to our local practice and do it there! Of course you would have to do a double blind, placebo controlled study! Keep spreading the word Dr. D and I’ll keep sharing!

    • David R. Hamilton PhD on June 1, 2017 at 8:37 am

      That would certainly be interesting, Angela! Hmmmmm.:-)

  2. Izabella Natrins on May 31, 2017 at 12:05 pm

    So exciting that science is finally showing us that we can use our mind to ‘medicate’ our body with NO side effects! Jo Marchany writes of similar in ‘Cure’ – fascinating book!

  3. Therese on June 1, 2017 at 2:48 pm

    Thank you for this post, David. It was a wonderful reminder to me of the importance and the power of expectation, particularly in regards to healing. Also, I was thinking that it is great that this study included the use initially of a drug then switched to using a placebo. Hopefully, studies like this can open the door for those that are close minded to mindbody (no separation intended in my wording) interactions and effects. Thank you for all the work you do and for raising awareness of the power of our mind to heal. Many blessings to you!

  4. Steve Kozma on June 1, 2017 at 4:54 pm

    I would prefer the name, ” believing effect”.
    ‘placebo’ is the content of believing; believing
    is the active process, placebos per se are innocuous.

  5. David R on June 1, 2017 at 9:28 pm

    Hmm this research m i g h t support the conclusions, but… it seems tenuous at best.
    – small study (42 patients in total)
    – experimental design isnt clear ( double blind RCT? two groups or several?)
    – key fact: ““The greater the number of previous apomorphine administrations, the larger the magnitude and the longer the duration of the clinical and neuronal placebo responses.”” ie: the more of the real drug we gave the patient the more benefit the placebo produced.
    Umm… maybe the benefits came from the real drug???
    I think the idea is interesting (and yes some FDA approved drugs are not a lot better than placebos, sad but true) but it needs work…

    • David R. Hamilton PhD on June 2, 2017 at 2:20 pm

      Hi David, I don’t think the benefits came from the real drug. I considered that at first too, but I checked and Apomorphine has a half life of around 30-40 minutes, so there shouldn’t be any traces of it left when the placebo was administered 24 hours later. Given the magnitude of the effect I think we can safely say that the entire effect was produced by the placebo. Fascinating study, I think.:-)

  6. Elizabeth Taylor on June 3, 2017 at 1:25 pm

    Hi, I’m with Julie in Turkey. My husband has had DBS, has an apo jab first thing then apo pump for the day. After 20 years of Parkinsons something for us to explore? Apo not so effective and off periods are debilitating his quality of life. Any hope for people such as us?

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